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Emiliano
Utente non iscritto
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« inserita:: Agosto 26, 2007, 17:51:34 pm » |
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Andréia Azevedo
Otosul-Otorrinolaringologia Sul-Fluminense, Department of Otolaryngology, Volta
Ridonda, Brasil
Introduction: Nowadays, the treatment of tinnitus is still a great challenge for theotolaryngologists. Many facts remain unknown in its hisiopatology , leading to many different therapies, with irregular results.
Memantine is a drug used in Alzheimer`s disease, due to its action in blockage of the NMDA receptor.
Aim: To evaluate efficacy and safety of memantine in the treatment of sensorineural tinnitus.
Materials and method: 60 patients with sensorineural tinnitus were divided in 2 groups in a double-blind prospective cross-over study against placebo, with evaluation of the therapeutical and side effects, using the THI (Tinnitus Handicap Inventory).
Results: This study didn`t show any statistically significant improvement in the THI than placebo. Meanwhile, some data suggest a possible late effect of memantine.
The incidence of side effects was low (9,4 %), but led to interruption in all the cases.
Conclusion: This study didn`t provide data to recomend memantine to treat sensorineural tinnitus, but a possible late effect of the drug should be evaluated in further studies.
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